Give Clothes, Give Hope!
Savers Fun Drive Fundraiser
Cure CLCN6 is now Collecting soft goods and books for a Savers Fun Drive!
Now through August 28, 2025, Cure CLCN6 is collecting items for a Fun Drive through Savers!
- Clothes
- Shoes/footwear
- Stuffed animals
- Towels, sheets, linens
- Books
Cure CLCN6 will be paid by weight for items collected and donated by Savers, who will resell or recycle the items. 100% of the proceeds will go towards our gene therapy project.
To make a donation or for more information, email contactus@cureclcn6.org or
call 909-280-5629.
*Goods are being collected in southern California.
About Cure CLCN6
Our Mission
Cure CLCN6 is dedicated to raising awareness of mutations on the CLCN6 gene, providing support and advocacy to affected children and their families, and funding the research and development of therapeutics, and ultimately a cure.
University of Massachusetts Chan Medical School
This research is led by:
To learn more about the Sena-Esteves lab and the
Gray-Edwards lab, please click the hyperlink on their names.
The CLCN6 Gene and Mutations
What is the CLCN6 Gene?
The human body has seven chloride channels, and the CLCN6 gene is the sixth channel (CL=Chloride, CN=Channel). This gene serves as a chloride/proton exchanger and functions as an ion gate transporter, which helps dispose of cellular waste.
CLCN6 Gene Mutations
Mutations can either be inherited from a parent or be "de novo," which means it occurred randomly when life was forming. Mutations on other chloride channels have been discovered before, but CLCN6 mutations have only been discovered in the past 20 years.
Children with this mutation often present with:
- severe developmental delays
- hypotonia (low muscle tone),
- epilepsy (often intractable and more frequent when sleeping)
- autism spectrum disorder
- Ataxia (Poor motor planning and coordination)
- Speech difficulties, including Apraxia of Speech
CLCN6 mutations are classified as a Lysosomal Storage Disorder and are found to be neurodegenerative in nature.
A presentation on CLCN6 mutations and Cure CLCN6 is available by clicking here.
How You Can Help
Donate
- GoFundMe
- Venmo: @Cure_CLCN6_Inc
Volunteer
- Community Events
- Fundraisers
- Research and prospecting
- Email contactus@cureclcn6.org
Follow Us
- Facebook: Cure CLCN6 and Paxton's Pioneers
- YouTube
Donate to Fund Paxton's Life Saving Gene Therapy
Your support and contributions will enable us to meet our goals and improve conditions. Your generous donation will fund our mission.
CURE CLCN6 IS A MEMBER OF THE Rare Epilepsy Network
Cure CLCN6 is a participating member of the Rare Epilepsy Network.
As reported by researchers at the Max Delbruck Center for Molecular Medicine, CLCN6 gene mutations cause severe epilepsy. The work we are doing will contribute to better understanding epilepsy and gene therapies as a treatment for this debilitating condition.
To learn more about REN, please click here or the image above.